Default connections for pipewire or assign rules for the connections based on what is running and sound devices available
Example rule 1: headphone mic is connected to OBS studio, Vcvrack is also connected to OBS. OBS studio has a monitor out that is connected to headphone speakers. Game audio is also connected to OBS. Mumble audio out is also connected to OBS. Headphone mic is connected to Mumble audio in.
Rule 2: OBS studio is not running. Wsjt audio is connected to usb soundevice 1. Game audio is connected to headphones. Mumble audio out and in is connected to headphone mic and headphone speakers.
Rule 3: focusrite usb sound device is present, It's connected to guitarix/DAW, guitarix is connected to headphone speakers.
OBS studio by the way needs this plugin to work with pipewire: https://github.com/dimtpap/obs-pipewire-audio-capture