I have occasional XRun when a new audio source is created or skipped. This happens about 20% of the time. Confirmed with firefox, mpv and vlc.
Steps to reproduce: Open an audio or video file in vlc, press play. Xrun happens.
pw-top shows same ammount of errors in applications and driver. The wiki doesn't offer any workaround for this type of xrun. Increasing headroom doesn't help.
I am running pipewire master (58d2fe44) on Manjaro.