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Those environment variables are not used by python.m4 since 2012. It is using python-config instead which is not present on Windows. so I don't think it has been working on Windows since then. See: https://git.gnome.org/browse/gobject-introspection/commit/m4/python.m4?id=46ccb9dfe51372b0fc51c93890088853d0f1617e https://bugzilla.gnome.org/show_bug.cgi?id=733067
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