Individual settings for horizontal and vertical Natural Scrolling
Depending on the device, it may make sense to enable Natural Scrolling on one axis but keep the other axis reversed. The Logitech MX Master 2S is one example, as the horizontal wheel always feels wrong (reversed) when compared to the vertical wheel.
This should require either one new setting, or changing the current
Natural Scrolling Enabled setting to have two booleans instead of one.
Mouse. (but possibly any other input device with scroll capabilities)